A group of terrorists led by General Boris (Aki Avni) kidnap the Russian prime minister's son and daughter and hold them hostage, demanding the release of their comrades within 72 hours. In addition, they have taken over the crippled Chernobyl Nuclear Power Plant and threaten to detonate it if their demands are not met. It is revealed that among the ranks of the terrorists is a Next-Generation UniSol (NGU) (Andrei Arlovski), who was smuggled in by rogue scientist Dr. Colin (Kerry Shale). U.S. forces bring in troops at the plant, but quickly retreat when the four UniSols revived for this mission are systematically eliminated by the NGU.
Meanwhile, former UniSol Luc Deveraux (Jean-Claude Van Damme), who is being rehabilitated in Switzerland by Dr. Sandra Fleming (Emily Joyce) to rejoin society, is taken back by the military to participate in the mission. As the deadline nears its expiration, the prime minister announces the release of 110 prisoners. The terrorists rejoice and shut off their bomb. Dr. Colin, however, is not pleased with the outcome, as he feels his side of the business is not done. As the NGU is programmed not to harm the terrorists, Dr. Colin unleashes his second UniSol: a cloned and upgraded version of Andrew Scott (Dolph Lundgren) - Deveraux's former nemesis, who quickly kills General Boris. Unfortunately, Dr. Colin never considered the mental instability of Scott, and he is immediately killed by his own creation. Scott then reactivates the bomb before heading out to hunt the children.